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This Article Full Text Full Text (PDF) All Versions of this Article: 553/1/3    most recent jphysiol.2003.052415v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Timmers, H. J. L. M. Articles by Lenders, J. W. M. Search for Related Content PubMed PubMed Citation Articles by Timmers, H. J. L. M. Articles by Lenders, J. W. M. Related Collections Review articles

Denervation of carotid baro- and chemoreceptors in humans

Henri J. L. M. Timmers*, Wouter Wieling†, John M. Karemaker‡ and Jacques W. M. Lenders*

Experimental denervation in animals has shown that carotid baro- and chemoreceptors play an eminent role in maintaining blood pressure and blood gas homeostasis. Denervation of carotid sinus baro- and chemoreceptors in humans may occur as a complication of invasive interventions on the neck or after experimental surgical treatment in asthma. In this topical review, the short- and long-term effects of carotid baro- and chemoreceptor denervation on the control of circulation and ventilation in humans are discussed. Carotid baroreceptor denervation in humans causes a persistent decrease in vagal and sympathetic baroreflex sensitivity and an increase in blood pressure variability; however, carotid denervation does not lead to chronic hypertension. Therefore, although carotid baroreceptors contribute to short-term blood pressure control, other receptors are able to maintain normal chronic blood pressure levels in the absence of carotid baroreceptors. Conversely, carotid chemoreceptor denervation leads to permanent abolition of normocapnic ventilatory responses to hypoxia and reduced ventilatory responses to hypercapnia.

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