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This Article Full Text Full Text (PDF) All Versions of this Article: 554/1/13    most recent jphysiol.2003.049494v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by O'Brien, T. P. Articles by Frankel, W. N. Search for Related Content PubMed PubMed Citation Articles by O'Brien, T. P. Articles by Frankel, W. N. Related Collections Review articles

The Jackson Laboratory, Bar Harbor, ME, USA

The study of genetic variation in mice offers a powerful experimental platform for understanding gene function. Complex trait analysis, gene-targeting and gene-trapping technologies, as well as insertional and chemical mutagenesis approaches are becoming increasingly sophisticated and provide a variety of options for cataloguing gene activities and interactions. In this review we discuss fundamental and practical concepts related to chemical mutagenesis and we highlight the growing list of strategies for performing mutagenesis screens in mice. Gene-driven and diverse types of phenotype-driven screens provide several options for the recovery of the invaluable variety of alleles generated by chemical mutagenesis. The unique advantages offered using chemical mutagenesis compare favourably to and complement the spectrum of approaches available for functional annotation of the mammalian genome.

(Received 17 June 2003; accepted after revision 16 October 2003; first published online 17 October 2003)
Corresponding author T. P. O'Brien: The Jackson Laboratory, Bar Harbor, ME, USA.  Email: tpo{at}jax.org

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