| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SYMPOSIUM REPORT |
Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
ATP released from damaged or inflamed tissues can act at P2X receptors expressed on primary afferent neurones. The resulting depolarization can initiate action potentials that are interpreted centrally as pain. P2X3 subunits are found in a subset of small-diameter, primary afferent neurones, some of which are also sensitive to capsaicin. They can form homo-oligomeric channels, or they can assemble with P2X2 subunits into hetero-oligomers. Studies with antagonists selective for P2X3-containing receptors, experiments with antisense oligonucleotides to reduce P2X3 subunit levels, and behavioural testing of P2X3 knock-out mice, all suggest a role for the P2X2/3 receptor in the signalling of chronic inflammatory pain and some features of neuropathic pain. The availability of such tools and experimental approaches promises to accelerate our understanding of the other physiological roles for P2X receptors on primary afferent neurones.
(Received 4 June 2003;
accepted after revision 25 June 2003;
first published online 27 June 2003)
Corresponding author R. A. North: Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. Email: r.a.north{at}sheffield.ac.uk
This article has been cited by other articles:
|
|
 |
|
  A. R. Light, R. W. Hughen, J. Zhang, J. Rainier, Z. Liu, and J. Lee Dorsal Root Ganglion Neurons Innervating Skeletal Muscle Respond to Physiological Combinations of Protons, ATP, and Lactate Mediated by ASIC, P2X, and TRPV1 J Neurophysiol, September 1, 2008; 100(3): 1184 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. H. Zhang, X. X. Chi, and G. D. Nicol Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway J. Physiol., July 1, 2008; 586(13): 3113 - 3127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tashiro, K. Okamoto, S. B. Milam, and D. A. Bereiter Differential Effects of Estradiol on Encoding Properties of TMJ Units in Laminae I and V at the Spinomedullary Junction in Female Rats J Neurophysiol, December 1, 2007; 98(6): 3242 - 3253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Gerevich, Z. S. Zadori, L. Koles, L. Kopp, D. Milius, K. Wirkner, K. Gyires, and P. Illes Dual Effect of Acid pH on Purinergic P2X3 Receptors Depends on the Histidine 206 Residue J. Biol. Chem., November 23, 2007; 282(47): 33949 - 33957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, Y. Gu, G.-W. Li, and L.-Y. M. Huang A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats J. Physiol., October 1, 2007; 584(1): 191 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D'Arco, R. Giniatullin, M. Simonetti, A. Fabbro, A. Nair, A. Nistri, and E. Fabbretti Neutralization of Nerve Growth Factor Induces Plasticity of ATP-Sensitive P2X3 Receptors of Nociceptive Trigeminal Ganglion Neurons J. Neurosci., August 1, 2007; 27(31): 8190 - 8201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Sokolova, A. Skorinkin, I. Moiseev, A. Agrachev, A. Nistri, and R. Giniatullin Experimental and Modeling Studies of Desensitization of P2X3 Receptors Mol. Pharmacol., July 1, 2006; 70(1): 373 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hausmann, J. Rettinger, Z. Gerevich, S. Meis, M. U. Kassack, P. Illes, G. Lambrecht, and G. Schmalzing The Suramin Analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic Acid (NF110) Potently Blocks P2X3 Receptors: Subtype Selectivity Is Determined by Location of Sulfonic Acid Groups Mol. Pharmacol., June 1, 2006; 69(6): 2058 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Burnstock Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev., March 1, 2006; 58(1): 58 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M Brierley, R Carter, W Jones III, L. Xu, D. R Robinson, G. A Hicks, G. F Gebhart, and L. A. Blackshaw Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice J. Physiol., August 15, 2005; 567(1): 267 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-Y. Xu and L.-Y. M. Huang Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors PNAS, August 10, 2004; 101(32): 11868 - 11873. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
