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TOPICAL REVIEW |
1 subunits
Department of Physiology, Ulm University, Ulm, Germany
Semi-conserved exon boundaries in members of the CACNA1 gene family result in recurring pre-mRNA splicing patterns. The resulting variations in the encoded pore-forming subunit of the voltage-gated calcium channel affect functionally significant regions, such as the vicinity of the voltage-sensing S4 segments or the intracellular loops that are important for protein interaction. In addition to generating functional diversity, RNA splicing regulates the quantitative expression of other splice isoforms of the same gene by producing transcripts with premature stop codons which encode two-domain or three-domain channels. An overview of some of the known splice isoforms of the 
1 calcium channel subunits and their significance is given.
(Received 4 August 2003;
accepted after revision 26 November 2003;
first published online 28 November 2003)
Corresponding author F. Lehmann-Horn, Abteilung Angewandte Physiologie, Universität Ulm, D-89081 Ulm, Germany. Email: frank.lehmann-horn{at}medizin.uni-ulm.de
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