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1 Département de physiologie, Centre de recherche en sciences neurologiques, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montréal, Qc, Canada H3C 3J72 GlaxoSmithKline, Institut de Biologie Cellulaire et de Morphologie, 1005 Lausanne, Switzerland
Hippocampal CA1 inhibitory interneurones control the excitability and synchronization of pyramidal cells, and participate in hippocampal synaptic plasticity. Pairing theta-burst stimulation (TBS) with postsynaptic depolarization, we induced long-term potentiation (LTP) of putative single-fibre excitatory postsynaptic currents (EPSCs) in stratum oriens/alveus (O/A) interneurones of mouse hippocampal slices. LTP induction was absent in metabotropic glutamate receptor 1 (mGluR1) knockout mice, was correlated with the postsynaptic presence of mGluR1a, and required a postsynaptic Ca2+ rise. Changes in paired-pulse facilitation and coefficient of variation indicated that LTP expression involved presynaptic mechanisms. LTP was synapse specific, occurring selectively at synapses modulated by presynaptic group II, but not group III, mGluRs. Furthermore, the TBS protocol applied in O/A induced a long-term increase of polysynaptic inhibitory responses in CA1 pyramidal cells, that was absent in mGluR1 knockout mice. These results uncover the mechanisms of a novel form of interneurone synaptic plasticity that can adaptively regulate inhibition of hippocampal pyramidal cells.
(Received 19 August 2003;
accepted after revision 10 December 2003;
first published online 12 December 2003)
Corresponding author J-C. Lacaille: Département de physiologie, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montréal, Qc, Canada H3C 3J7. Email: jean-claude.lacaille{at}umontreal.ca
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