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This Article Full Text Full Text (PDF) All Versions of this Article: 558/2/369    most recent jphysiol.2004.064881v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hinke, S. A. Articles by Schuit, F. C. Search for Related Content PubMed PubMed Citation Articles by Hinke, S. A. Articles by Schuit, F. C. Related Collections Review articles

¹ Diabetes Research Center, Vrije Universiteit Brussel, Belgium² Gene Expression Unit, Afdeling Biochemie, Katholieke Universiteit Leuven, Belgium

It is well established that the acute rise in plasma glucose and in the incretin hormones glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (7–36) amide (GLP-1), as occurs during a meal, is of pivotal importance in regulating the minute-to-minute output of insulin from pancreatic ß cells. In addition to this well studied acute effect, both glucose and incretin hormones have been recently observed to determine the future secretory responsiveness of the cells. Such plasticity of the insulin secretory competence would imply that glucose and incretins not only act during the present meal, but also help to prepare the ß cells to function during the subsequent meal. Evidence supporting this hypothesis is growing as a result of physiological studies of cultured ß cells (either primary cells or ß cell lines), as well as from an increasing number of large-scale gene expression studies, exploring transcriptional and post-transcriptional events in genes regulated by glucose and incretins. On the basis of this hypothesis, one can speculate that genetic or environmental disturbances of plasticity of the insulin secretory competence is one aspect of ß cell dysfunction that can contribute to the aetiology of type 2 diabetes.

(Received 19 March 2004; accepted after revision 1 June 2004; first published online 4 June 2004)
Corresponding author F. C. Schuit: Gene Expression Unit, Division of Biochemistry, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium. Email: frans.schuit{at}med.kuleuven.ac.be

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