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1 Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France2 Department of Physiology and Experimental Pathophysiology, University of Erlangen-Nuremburg, Universitätsstrasse 17, D-91054 Erlangen, Germany3 Department of Physiology, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria4 INSERM U583, Physiopathologie et thérapie des déficits sensoriels et moteurs, 71 rue de Navacelles, 34090 Montpellier, France
Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C. elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechanosensitive cation channels. Mammalian degenerin homologues, the H+-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.
(Received 6 April 2004;
accepted after revision 24 May 2004;
first published online 28 May 2004)
Corresponding author M. Lazdunski: Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France. Email: ipmc{at}ipmc.cnrs.fr
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