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1 101 Theory, No. 250, Department of Psychiatry and Human Behaviour, University of California, Irvine, CA 92612-1695, USA
2 Department of Obstetrics and Gynecology, University of California Los Angeles School of Medicine, Harbour/UCLA Medical Center, Torrance, CA 90509, USA
3 Department of Neurobiology and Behaviour, University of California, Irvine, CA 92697, USA
Sharp waves (SPWs) occur in the hippocampal EEG during behaviours such as alert immobility and slow-wave sleep. Despite their widespread occurrence across brain regions and mammalian species, the functional importance of SPWs remains unknown. Experiments in the present study indicate that long-term potentiation (LTP) is significantly impaired in slices, prepared from the temporal aspect of rat hippocampus, that spontaneously generate SPW activity. This was probably not due to anatomical and/or biochemical abnormalities in temporal slices because stable LTP was uncovered in field CA1 when SPWs were eliminated by severing the projection from CA3. The same procedure did not alter LTP in slices lacking SPWs. Robust and stable LTP was obtained in the presence of SPWs in slices treated with an adenosine A1 receptor antagonist, a finding that links the present results to mechanisms related to the LTP reversal effect. In accord with this, single stimulation pulses delivered intermittently in a manner similar to the SPW pattern interfered with LTP to a similar degree as spontaneous SPWs. Taken together, these results suggest the possibility that SPWs in the hippocampus constitute a neural mechanism for forgetting.
(Received 13 May 2004;
accepted after revision 9 June 2004;
first published online 11 June 2004)
Corresponding author L. L. Colgin: 101 Theory, No. 250, Department of Psychiatry and Human Behaviour, University of California, Irvine, CA 92612-1695, USA. Email: lcolgin{at}uci.edu
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