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Department of Environmental Health, Life Science and Human Technology, Nara Women's University, Kita-Uoya Nishimachi, Nara, 630-8506, Japan
The present study aimed to determine the impact of REM sleep and grooming on the baroreflex stimulus–response curve for renal sympathetic nerve activity (RSNA). At least 3 days before study, Wistar female rats (n= 12) were chronically implanted with catheters to measure systemic arterial pressure (Pa) and to intravenously infuse vasoactive drugs. In addition, electrodes were placed for measurements of RSNA, electroencephalogram, trapezius electromyogram and electrocardiogram. The baroreflex curve for RSNA was determined by changing Pa using rapid intravenous infusions of phenylephrine and nitroprusside and then fitted to an inverse sigmoid function curve. REM sleep induced a vertical suppression of the Pa–RSNA baroreflex curve, which was characterized by significant decreases in the maximum response (by 72.0%, P < 0.05) and the maximum gain (by 4.02% mmHg–1, P < 0.05) compared with NREM sleep level. Grooming shifted the Pa–RSNA baroreflex curve upward and to the right, which was associated with increases in the maximum response (by 45.2%, P < 0.05), the minimum response (by 20.7%, P < 0.05) and the pressure at the centring point (by 11.1 mmHg, P < 0.05). These data suggest that the Pa–RSNA baroreflex curve was shifted acutely and differently in a state-dependent manner during natural sleep and wake cycle in rats.
(Received 15 March 2004;
accepted after revision 4 June 2004;
first published online 11 June 2004)
Corresponding author K. Miki: Department of Environmental Health, Life Science and Human Technology, Nara Women's University, Kita-Uoya Nishimachi, Nara, 630-8506, Japan. Email: k.miki{at}cc.nara-wu.ac.jp
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