HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 559/3/875    most recent jphysiol.2004.069534v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huemmeke, M. Articles by Mittmann, T. Search for Related Content PubMed PubMed Citation Articles by Huemmeke, M. Articles by Mittmann, T.

Department of Neurophysiology, Ruhr-University Bochum, D-44780 Bochum, Germany

There is emerging evidence that injury of the cerebral cortex is followed by processes of enhanced neuroplasticity. In the present study, we investigate the functional properties of NMDA receptors (NMDARs) in the surround of focal lesions with recordings of extracellular field potentials (FPs) in acute slices of rat visual cortex at survival times of 2–6 days. FPs were recorded in cortical layer III lateral to the lesion, while long-term potentiation (LTP) was induced by theta-burst stimulation (TBS) in layer IV. The predominantly AMPA receptor-mediated FPs displayed a significantly enhanced LTP in the surround of the lesion at distances of 2–3.2 mm. The LTP was completely blocked by the NMDAR antagonist D-AP5. Ifenprodil, an antagonist of NMDARs containing the NR2B subunit, only slightly affected the LTP in slices from sham-operated animals, but significantly reduced the LTP in slices from lesioned rats. We quantitatively analysed the proportion of NMDARs containing the NR2B subunit after lesions by applying ifenprodil to pharmacologically isolated NMDAR-FPs. The NR2B antagonist reduced the NMDAR-FPs significantly more strongly at distances of 2.0–3.2 mm from the border of the lesion. This indicates that the early phase of increased synaptic long-term plasticity in the surround of cortical lesions is accompanied by an up-regulation of NMDARs containing the NR2B subunit.

(Received 7 June 2004; accepted after revision 22 July 2004; first published online 29 July 2004)
Corresponding author T. Mittmann: Department of Neurophysiology, MA 4/149, Ruhr-University Bochum, D-44780 Bochum, Germany. Email: mittmann{at}neurop.ruhr-uni-bochum.de

This article has been cited by other articles:

				A. Haghikia, E. Mergia, A. Friebe, U. T. Eysel, D. Koesling, and T. Mittmann Long-Term Potentiation in the Visual Cortex Requires Both Nitric Oxide Receptor Guanylyl Cyclases J. Neurosci., January 24, 2007; 27(4): 818 - 823. [Abstract] [Full Text] [PDF]

				N. Origlia, N. Kuczewski, E. Aztiria, D. Gautam, J. Wess, and L. Domenici Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex J. Physiol., December 15, 2006; 577(3): 829 - 840. [Abstract] [Full Text] [PDF]

				H.-Y. He, W. Hodos, and E. M. Quinlan Visual deprivation reactivates rapid ocular dominance plasticity in adult visual cortex. J. Neurosci., March 15, 2006; 26(11): 2951 - 2955. [Abstract] [Full Text] [PDF]