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Symposium Reports |
1 School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
Abstract
All three forms of recombinant low voltage-activated T-type Ca2+ channels (Cav3.1, Cav3.2 and Cav3.3) exhibit a small, though clearly evident, window T-type Ca2+ current (ITwindow) which is also present in native channels from different neuronal types. In thalamocortical (TC) and nucleus reticularis thalami (NRT) neurones, and possibly in neocortical cells, an ITwindow-mediated bistability is the key cellular mechanism underlying the expression of the slow (< 1 Hz) sleep oscillation, one of the fundamental EEG rhythms of non-REM sleep. As the ITwindow-mediated bistability may also represent one of the cellular mechanisms underlying the expression of high frequency burst firing in awake conditions, ITwindow is of critical importance in neuronal population dynamics associated with different behavioural states.
(Received 28 September 2004;
accepted after revision 19 October 2004;
first published online 21 October 2004)
Corresponding author V. Crunelli: School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK. Email: crunelli{at}cardiff.ac.uk
In memory of Eberhard H. Buhl. This report was presented at The Journal of Physiology Symposium in honour of the late Eberhard H. Buhl on Structure/Function Correlates in Neurons and Networks, Leeds, UK, 10 September 2004. It was commissioned by the Editorial Board and reflects the views of the authors.
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