| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
2 Department of Internal Medicine, University of Texas South-western Medical Center, Dallas, TX 75235, USA
Two experiments were performed to identify whether nitric oxide (NO) inhibits sympathetically mediated vasoconstriction in human skin. In eight subjects increasing doses of sodium nitroprusside (SNP; 8.4 x 10–6–8.4 x 10–3M) were administered via intradermal microdialysis. At each dose of SNP, cutaneous vasoconstrictor responsiveness was assessed during a 3 min whole-body cold stress. The relative reduction in forearm cutaneous vascular conductance (CVC) during the cold stress was significantly attenuated for SNP doses greater than 8.4 x 10–4M (control: 63.0 ± 4.1%, SNP 8.4 x 10–6M: 57.1 ± 4.7%, SNP 8.4 x 10–5M: 57.0 ± 3.6%, SNP 8.4 x 10–4M: 44.5 ± 5.4% and SNP 8.4 x 10–3M: 28.8 ± 7.9%). The second experiment was performed to identify whether this response was due to NO attenuating sympathetically mediated vasoconstriction or due to a non-specific effect of an elevated CVC secondary to SNP administration. In seven subjects forearm CVC during a whole-body cold stress was assessed at two sites: at a site dilated via microdialysis administration of SNP and at a site dilated with isoproterenol (ISO). CVC was not different between sites prior to (SNP: 0.42 ± 0.11; ISO: 0.46 ± 0.11 AU mmHg–1 (AU, arbitrary units), P > 0.05) or following drug infusion (SNP: 1.36 ± 0.21; ISO: 1.27 ± 0.23 AU mmHg–1, P > 0.05). The reduction in CVC during the subsequent cold stress was significantly less at the SNP site (38.1 ± 6.2%) relative to the ISO site (65.0 ± 5.5%; P= 0.007). These data suggest NO is capable of inhibiting sympathetically mediated vasoconstriction in the cutaneous vasculature.
(Received 17 September 2004;
accepted after revision 8 November 2004;
first published online 11 November 2004)
Corresponding author C. G. Crandall: Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA.
This article has been cited by other articles:
|
|
 |
|
  M. Shibasaki, S. Durand, S. L. Davis, J. Cui, D. A. Low, D. M. Keller, and C. G. Crandall Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction J. Physiol., December 1, 2007; 585(2): 627 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Hodges, W. A. Kosiba, K. Zhao, G. E. Alvarez, and J. M. Johnson The role of baseline in the cutaneous vasoconstrictor responses during combined local and whole body cooling in humans Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3187 - H3192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Low, M. Shibasaki, S. L. Davis, D. M. Keller, and C. G. Crandall Does local heating-induced nitric oxide production attenuate vasoconstrictor responsiveness to lower body negative pressure in human skin? J Appl Physiol, May 1, 2007; 102(5): 1839 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Charkoudian, M. J. Joyner, S. A. Barnes, C. P. Johnson, J. H. Eisenach, N. M. Dietz, and B. G. Wallin Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1378 - H1383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Hodges, K. Zhao, W. A. Kosiba, and J. M. Johnson The involvement of nitric oxide in the cutaneous vasoconstrictor response to local cooling in humans J. Physiol., August 1, 2006; 574(3): 849 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Houghton, J. R. Meendering, B. J. Wong, and C. T. Minson Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin J. Physiol., May 1, 2006; 572(3): 811 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Yamazaki, R. Sone, K. Zhao, G. E. Alvarez, W. A. Kosiba, and J. M. Johnson Rate dependency and role of nitric oxide in the vascular response to direct cooling in human skin J Appl Physiol, January 1, 2006; 100(1): 42 - 50. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
