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1 Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
This study investigated the developmental and nutritional programming of uncoupling protein-2 (UCP2), glucocorticoid receptor (GR) and 11ß-hydroxysteroid dehydrogenase type 1 (11ßHSD1) mRNA in the sheep lung from the time of uterine attachment to 6 months of age. The effect of maternal nutrient restriction on lung development was determined in early to mid gestation (i.e. 28–80 days gestation, period of maximal placental growth, and embryonic and pseudoglandular stages of fetal lung development) and late gestation (i.e. 110–147 days gestation, period of maximal fetal growth, and canalicular and saccular stages of fetal lung development). Fetal lungs were sampled at 80 and 140 days (term 
148 days) gestation, and sheep lungs at 1, 7, 30 days and 6 months. GR and 11ßHSD1 mRNA were maximal at 140 days gestation, whereas UCP2 mRNA peaked at 1 day of age and then declined with postnatal age. Maternal nutrient restriction in both early-to-mid and late gestation had no effect on lung weight, but increased UCP2, GR and 11ßHSD1 mRNA abundance at every sampling age. These findings suggest that the developmental ontogeny of UCP2 mRNA in the ovine lung is under local glucocorticoid hormone action and that maternal nutrient restriction has long-term consequences for UCP2 and GR mRNA abundance in the lung irrespective of its timing.
(Received 14 January 2005;
accepted after revision 10 March 2005;
first published online 17 March 2005)
Corresponding author M. E. Symonds: Academic Division of Child Health, School of Human Development, Queen's Medical Centre, University Hospital, Nottingham NG7 2UH, UK. Email: michael.symonds{at}nottingham.ac.uk
This article has been cited by other articles:
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M G Gnanalingham, P Williams, V Wilson, J Bispham, M A Hyatt, A Pellicano, H Budge, T Stephenson, and M E Symonds Nutritional manipulation between early to mid-gestation: effects on uncoupling protein-2, glucocorticoid sensitivity, IGF-I receptor and cell proliferation but not apoptosis in the ovine placenta Reproduction, October 1, 2007; 134(4): 615 - 623. [Abstract] [Full Text] [PDF]
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D P Yakubu, A Mostyn, V Wilson, S Pearce, M C Alves-Guerra, C Pecqueur, B Miroux, H Budge, T Stephenson, and M E Symonds Different effects of maternal parity, cold exposure and nutrient restriction in late pregnancy on the abundance of mitochondrial proteins in the kidney, liver and lung of postnatal sheep Reproduction, June 1, 2007; 133(6): 1241 - 1252. [Abstract] [Full Text] [PDF]
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M. Grino Prenatal nutritional programming of central obesity and the metabolic syndrome: role of adipose tissue glucocorticoid metabolism Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2005; 289(5): R1233 - R1235. [Full Text] [PDF]
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M G Gnanalingham, A Mostyn, J Wang, R Webb, D H Keisler, N Raver, M C Alves-Guerra, C Pecqueur, B Miroux, T Stephenson, et al. Tissue-specific effects of leptin administration on the abundance of mitochondrial proteins during neonatal development J. Endocrinol., October 1, 2005; 187(1): 81 - 88. [Abstract] [Full Text] [PDF]
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