HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 566/2/295    most recent jphysiol.2005.087387v2 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Irvine, R. F Search for Related Content PubMed PubMed Citation Articles by Irvine, R. F

¹ Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK

Abstract

When viewing the changes in our understanding of inositides over the last 20 years, it is difficult to know whether to be more impressed by the proliferation in the number of inositides themselves (e.g. seven polyphosphoinositol lipids, more than 30 inositol phosphates), or by the number of functions for each. This review will focus on two specific aspects of this diversity: the evolution of the polyphosphoinositides, and the synthesis and functions of the higher inositol phosphates.

(Received 24 March 2005; accepted after revision 27 April 2005; first published online 28 April 2005)
Corresponding author R. F. Irvine: Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK. Email: rfi20{at}cam.ac.uk

The Physiological Society Annual Review Prize Lecture was given on 19 December 2004 at King's College London.

This article has been cited by other articles:

				J. C. Otto, P. Kelly, S.-T. Chiou, and J. D. York Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases PNAS, October 2, 2007; 104(40): 15653 - 15658. [Abstract] [Full Text] [PDF]

				Y. Gao and H.-y. Wang Inositol Pentakisphosphate Mediates Wnt/beta-Catenin Signaling J. Biol. Chem., September 7, 2007; 282(36): 26490 - 26502. [Abstract] [Full Text] [PDF]