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1 Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, August Krogh Building, Copenhagen, Denmark
2 Copenhagen Muscle Research Centre, Institute for Sport and Exercise Sciences, Copenhagen, Denmark
Skeletal muscle releases potassium during activity. Interstitial potassium accumulation is important for muscle function and the development of fatigue resulting from exercise. In the present study we used sodium citrate ingestion as a tool to investigate the relationship between interstitial H+ concentration and K+ accumulation during exercise. Seven healthy subjects performed one-legged knee-extensor exercise on two separate days with and without sodium citrate ingestion. Interstitial H+ and K+ concentrations were measured with the microdialysis technique. Citrate ingestion reduced the plasma H+ concentration and increased the plasma HCO3– concentration. Citrate had no effect on interstitial H+ at rest. The increase in interstitial H+ concentration during intense exercise was significantly lower (P < 0.05) with citrate ingestion compared to control (peak interstitial H+ concentration 79 versus 131 nM). After 3 min of exercise interstitial K+ concentration was reduced (P < 0.05) in the citrate (alkalosis) compared to the control experiment (8.0 ± 0.9 versus 11.0 ± 2 mM) and interstitial K+ concentration remained lower during the rest of the exercise period. The present study demonstrated a link between interstitial H+ and K+ accumulation, which may be through the ATP-sensitive K+ channels (KATP channels), which are sensitive to changes in H+.
(Received 17 March 2005;
accepted after revision 26 April 2005;
first published online 28 April 2005)
Corresponding author C. Juel: Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen, Denmark. Email: cjuel{at}aki.ku.dk
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