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Symposium reports |
1 Department of Cell and Developmental Biology
2 Graduate program in Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
The Na exchanger regulatory factor (NHERF) family of epithelial-enriched PDZ domain scaffolding proteins plays important roles in maintaining and regulating epithelial cell function. The NHERFs exhibit some overlap in tissue distribution and binding partners, suggesting redundant functions. Yet, it is clear that each NHERF protein exhibits distinct properties, translating into unique cellular functions. The work summarized in this review suggests the most recently identified family member, NHERF4, is the most divergent. Additional investigation is needed, however, to understand more completely the role of NHERF4 in the context of the NHERF family.
(Received 21 June 2005;
accepted after revision 28 June 2005;
first published online 1 July 2005)
Corresponding author S. L. Milgram: Department of Cell and Developmental Biology, The University of North Carolina at Chapel Hill, CB 7090, Chapel Hill, NC 27599, USA. Email: milg{at}med.unc.edu
This report was presented at The Journal of Physiology Symposium on PDZ domain scaffolding proteins and their functions in polarized cells, San Diego, CA, USA, 4 April 2005. It was commissioned by the Editorial Board and reflects the views of the authors.
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