| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Symposium reports |
1 Center for Translational Neuroscience, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
The TRPV4 ion channel, previously named vanilloid receptor-related osmotically activated channel (VR-OAC), functions in vivo in the transduction of osmotic and mechanical stimuli. In trpv4 null mice, TRPV4 was found to be necessary for the maintenance of systemic osmotic equilibrium, and for normal thresholds in response to noxious mechanical stimuli. In a Caenorhabditis elegans TRPV mutant transgenic for mammalian TRPV4, the mammalian transgene was directing the osmotic and mechanical avoidance response in the context of the ASH ‘nociceptive’ neurone. Molecular mechanisms of gating of TRPV4 in vivo are not known at this point and have to be determined.
(Received 19 April 2005;
accepted after revision 15 June 2005;
first published online 16 June 2005)
Corresponding author W. Liedtke: Center for Translational Neuroscience, Duke University Medical Center, Box 2900, Durham, NC 27710, USA. Email: wolfgang{at}neuro.duke.edu
This article has been cited by other articles:
|
|
 |
|
  S. A. Gradilone, A. I. Masyuk, P. L. Splinter, J. M. Banales, B. Q. Huang, P. S. Tietz, T. V. Masyuk, and N. F. LaRusso Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion PNAS, November 27, 2007; 104(48): 19138 - 19143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Garcia-Sanz, P. Valente, A. Gomis, A. Fernandez-Carvajal, G. Fernandez-Ballester, F. Viana, C. Belmonte, and A. Ferrer-Montiel A Role of the Transient Receptor Potential Domain of Vanilloid Receptor I in Channel Gating J. Neurosci., October 24, 2007; 27(43): 11641 - 11650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Orlov and A. A. Mongin Salt-sensing mechanisms in blood pressure regulation and hypertension Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2039 - H2053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Alvarez, J. A. King, D. Weber, E. Addison, W. Liedtke, and M. I. Townsley Transient Receptor Potential Vanilloid 4-Mediated Disruption of the Alveolar Septal Barrier: A Novel Mechanism of Acute Lung Injury Circ. Res., October 27, 2006; 99(9): 988 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Liu, B. Bandyopadhyay, T. Nakamoto, B. Singh, W. Liedtke, J. E. Melvin, and I. Ambudkar A Role for AQP5 in Activation of TRPV4 by Hypotonicity: CONCERTED INVOLVEMENT OF AQP5 AND TRPV4 IN REGULATION OF CELL VOLUME RECOVERY J. Biol. Chem., June 2, 2006; 281(22): 15485 - 15495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Nilius and S. O Sage TRP channels: novel gating properties and physiological functions J. Physiol., August 15, 2005; 567(1): 33 - 34. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
