| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, IL 60208, USA
2 Section of Neurobiology, University of Texas at Austin, Austin, TX 7812, USA
3 Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA
We performed simultaneous patch-electrode recordings from the soma and apical dendrite of CA1 pyramidal neurons in hippocampal slices, in order to determine the degree of voltage attenuation along CA1 dendrites. Fifty per cent attenuation of steady-state somatic voltage changes occurred at a distance of 238 µm from the soma in control and 409 µm after blocking the hyperpolarization-activated (H) conductance. The morphology of three neurons was reconstructed and used to generate computer models, which were adjusted to fit the somatic and dendritic voltage responses. These models identify several factors contributing to the voltage attenuation along CA1 dendrites, including high axial cytoplasmic resistivity, low membrane resistivity, and large H conductance. In most cells the resting membrane conductances, including the H conductances, were larger in the dendrites than the soma. Simulations suggest that synaptic potentials attenuate enormously as they propagate from the dendrite to the soma, with greater than 100-fold attenuation for synapses on many small, distal dendrites. A prediction of this powerful EPSP attenuation is that distal synaptic inputs are likely only to be effective in the presence of conductance scaling, dendritic excitability, or both.
(Received 19 March 2005;
accepted after revision 6 July 2005;
first published online 7 July 2005)
Corresponding author N. Spruston: 2205 Tech Dr., Evanston, IL 60208-3520, USA. Email: spruston{at}northwestern.edu
This article has been cited by other articles:
|
|
 |
|
  R. Narayanan and D. Johnston The h Channel Mediates Location Dependence and Plasticity of Intrinsic Phase Response in Rat Hippocampal Neurons J. Neurosci., May 28, 2008; 28(22): 5846 - 5860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Raymond Different requirements for action potentials in the induction of different forms of long-term potentiation J. Physiol., April 1, 2008; 586(7): 1859 - 1865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hong and W. N. Ross Priming of intracellular calcium stores in rat CA1 pyramidal neurons J. Physiol., October 1, 2007; 584(1): 75 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Ying, F. Jia, S. Y. Abbas, F. Hofmann, A. Ludwig, and P. A. Goldstein Dendritic HCN2 Channels Constrain Glutamate-Driven Excitability in Reticular Thalamic Neurons J. Neurosci., August 8, 2007; 27(32): 8719 - 8732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schmidt-Hieber, P. Jonas, and J. Bischofberger Subthreshold Dendritic Signal Processing and Coincidence Detection in Dentate Gyrus Granule Cells J. Neurosci., August 1, 2007; 27(31): 8430 - 8441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Perreault and M. Raastad Contribution of morphology and membrane resistance to integration of fast synaptic signals in two thalamic cell types J. Physiol., November 15, 2006; 577(1): 205 - 220. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
