| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Rapid Reports |
1 Division of Neuroscience, John Curtin School of Medical Research, Canberra, ACT 0200, Australia
2 Department of Physiology, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601, Japan
When intracellular recordings were made from the circular layer of the intact muscular wall of the isolated guinea pig gastric corpus, an ongoing regular high frequency discharge of slow waves was detected even though this region lacked myenteric interstitial cells. When slow waves were recorded from preparations consisting of both the antrum and the corpus, slow waves of identical frequency, but with different shapes, were generated in the two regions. Corporal slow waves could be distinguished from antral slow waves by their time courses and amplitudes. Corporal slow waves, like antral slow waves, were abolished by buffering the internal concentration of calcium ions, [Ca2+]i, to low levels, or by caffeine, 2-aminoethoxydiphenyl borate or the chloride channel blocker DIDS. Corporal preparations demonstrated an ongoing discharge of unitary potentials, as has been found in all other tissues containing interstitial cells. The experiments show that the corpus provides the dominant pacemaker activity which entrains activity in other regions of the stomach and it is suggested that this activity is generated by corporal intramuscular interstitial cells.
(Received 31 August 2005;
accepted after revision 12 October 2005;
first published online 13 October 2005)
Corresponding author G. D. S. Hirst: Division of Neuroscience, John Curtin School of Medical Research, Canberra, ACT 0200, Australia. Email: david.hirst{at}anu.edu.au
This article has been cited by other articles:
|
|
 |
|
  K. M. Sanders and S. M. Ward Kit mutants and gastrointestinal physiology J. Physiol., January 1, 2007; 578(1): 33 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, D. Redelman, S. Ro, S. M. Ward, T. Ordog, and K. M. Sanders Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine Am J Physiol Cell Physiol, January 1, 2007; 292(1): C497 - C507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. S. Hirst and F. R. Edwards Electrical events underlying organized myogenic contractions of the guinea pig stomach J. Physiol., November 1, 2006; 576(3): 659 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Suzuki, Y. Kito, H. Hashitani, and E. Nakamura Factors modifying the frequency of spontaneous activity in gastric muscle J. Physiol., November 1, 2006; 576(3): 667 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakayama, K. Shimono, H.-N. Liu, H. Jiko, N. Katayama, T. Tomita, and K. Goto Pacemaker phase shift in the absence of neural activity in guinea-pig stomach: a microelectrode array study J. Physiol., November 1, 2006; 576(3): 727 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Costa All together now: from pacemakers to gastric peristalsis J. Physiol., February 15, 2006; 571(1): 1 - 1. [Full Text] [PDF]
|
|
|
|
|
|
G. D. S. Hirst, A. P. Garcia-Londono, and F. R. Edwards Propagation of slow waves in the guinea-pig gastric antrum J. Physiol., February 15, 2006; 571(1): 165 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Edwards and G. D. S. Hirst An electrical analysis of slow wave propagation in the guinea-pig gastric antrum J. Physiol., February 15, 2006; 571(1): 179 - 189. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
