J Physiol Society Meetings
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Volume 569, Number 2, 643-653, December 1, 2005 DOI: 10.1113/jphysiol.2005.098012
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
569/2/643    most recent
jphysiol.2005.098012v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Solomonia, R. O.
Right arrow Articles by Horn, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Solomonia, R. O.
Right arrow Articles by Horn, G.
Related Collections
Right arrow Integrative

Ca2+/calmodulin protein kinase II and memory: learning-related changes in a localized region of the domestic chick brain

Revaz O. Solomonia1, Adam Kotorashvili1, Tamar Kiguradze1, Brian J. McCabe2 and Gabriel Horn2

1 Institute of Physiology, Georgian Academy of Sciences, 14 L. Gotua Str., Tbilisi 380060, Republic of Georgia
2 Sub-Department of Animal Behaviour, University of Cambridge, Madingley, Cambridge CB3 8AA, UK

The role of calcium/calmodulin-dependent protein kinase II (CaMKII) in the recognition memory of visual imprinting was investigated. Domestic chicks were exposed to a training stimulus and learning strength measured. Trained chicks, together with untrained chicks, were killed either 1 h or 24 h after training. The intermediate and medial hyperstriatum ventrale/mesopallium (IMHV/IMM), a forebrain memory storage site, was removed together with a control brain region, the posterior pole of the neostriatum/nidopallium (PPN). Amounts of membrane total {alpha}CaMKII (tCaMKII) and Thr286-autophosphorylated {alpha}CaMKII (apCAMKII) were measured. For the IMHV/IMM 1 h group, apCaMKII amount and apCAMKII/tCaMKII increased as chicks learned. The magnitude of the molecular changes were positively correlated with learning strength. No learning-related effects were observed in PPN, or in either region at 24 h. These results suggest that CaMKII is involved in the formation of memory but not in its maintenance.

(Received 2 September 2005; accepted after revision 20 September 2005; first published online 22 September 2005)
Corresponding author G. Horn: Sub-Department of Animal Behaviour, Madingley, Cambridge CB3 8AA, UK. Email: gh105{at}cam.ac.uk






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 The Physiological Society.