HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 570/2/209    most recent jphysiol.2005.097873v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rosen, M. R. Articles by Cohen, I. S. Search for Related Content PubMed PubMed Citation Articles by Rosen, M. R. Articles by Cohen, I. S. Related Collections Review articles

¹ Departments of Pharmacology and Pediatrics, Center for Molecular Therapeutics, College of Physicians & Surgeons of Columbia University, New York, NY, USA
² Department of Physiology and Biophysics, Institute of Molecular Cardiology, Stony Brook University, Stony Brook, NY, USA

‘Cardiac memory’ describes an electrocardiographic T wave vector change, recorded during normal sinus rhythm that reflects the QRS complex vector during prior periods of ventricular pacing or arrhythmia. In this brief review we consider the mechanisms responsible for cardiac memory, which offer a unique window for relating molecular determinants of repolarization to their expression in the function of ion channels and in the electrophysiology of the heart. Understanding the steps that translate the molecular mechanisms for memory into clinical expression in this relatively straightforward model facilitates our comprehension of the complex pathways that order normal cardiac repolarization and repolarization changes.

(Received 1 September 2005; accepted after revision 7 November 2005; first published online 10 November 2005)
Corresponding author M. R. Rosen: Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, 630 West 168 Street, PH7West-321, New York, NY 10032, USA. Email: mrr1{at}columbia.edu