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J Physiol Volume 570, Number 3, 437-444, February 1, 2006 DOI: 10.1113/jphysiol.2005.097238
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TOPICAL REVIEW

Preparing for the first breath: prenatal maturation of respiratory neural control

John J. Greer1, Gregory D. Funk1,2 and Klaus Ballanyi1

1 Department of Physiology, Perinatal Research Centre, 513 HMRC, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
2 Department of Physiology, Faculty of Medicine and Dentistry, University of Auckland, Private Bag 92019, Auckland, New Zealand

By birth, the regulatory neural network responsible for respiratory control is capable of generating robust rhythm-driving ventilation that can adjust to homeostatic needs. The advent of in vitro models isolated from prenatal rodents has significantly advanced our understanding of these processes. In this topical review, we examine the development of medullary respiratory rhythm-generating centres and phrenic motoneurone–diaphragm properties during the prenatal period.

(Received 23 August 2005; accepted after revision 7 November 2005; first published online 10 November 2005)
Corresponding author J. J. Greer: University of Alberta, Department of Physiology, 513 HMRC, Edmonton, AB, Canada T6G 2S2. Email: john.greer{at}ualberta.ca




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