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This Article Full Text Full Text (PDF) All Versions of this Article: 571/1/75    most recent jphysiol.2005.100685v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hvalby, O. Articles by Walaas, S. I. Search for Related Content PubMed PubMed Citation Articles by Hvalby, O. Articles by Walaas, S. I. Related Collections Neuroscience

¹ Molecular Neurobiology Research Group, Institute of Basic Medical Sciences, University of Oslo, Norway
² Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA

The effects of synapsin proteins on synaptic transmission from vesicles in the readily releasable vesicle pool have been examined by comparing excitatory synaptic transmission in hippocampal slices from mice devoid of synapsins I and II and from wild-type control animals. Application of stimulus trains at variable frequencies to the CA3-to-CA1 pyramidal cell synapse suggested that, in both genotypes, synaptic responses obtained within 2 s stimulation originated from readily releasable vesicles. Detailed analysis of the responses during this period indicated that stimulus trains at 2–20 Hz enhanced all early synaptic responses in the CA3-to-CA1 pyramidal cell synapse, but depressed all early responses in the medial perforant path-to-granule cell synapse. The synapsin-dependent part of these responses, i.e. the difference between the results obtained in the transgene and the wild-type preparations, showed that in the former synapse, the presence of synapsins I and II minimized the early responses at 2 Hz, but enhanced the early responses at 20 Hz, while in the latter synapse, the presence of synapsins I and II enhanced all responses at both stimulation frequencies. The results indicate that synapsins I and II are necessary for full expression of both enhancing and decreasing modulatory effects on synaptic transmission originating from the readily releasable vesicles in these excitatory synapses.

(Received 27 October 2005; accepted after revision 29 November 2005; first published online 1 December 2005)
Corresponding authorØ. Hvalby: Molecular Neurobiology Research Group, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, 0317 Oslo, Norway. Email: o.c.hvalby{at}medisin.uio.no

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