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J Physiol Volume 575, Number 2, 353-359, September 1, 2006 DOI: 10.1113/jphysiol.2006.112623
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Topical Review

Microarrays and the microscope: balancing throughput with resolution

Giovanni Coppola1 and Daniel H. Geschwind1–3

Departments of
1 Neurology, Program in Neurogenetics
2 Psychiatry
3 Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA

The cellular complexity of the brain is a major issue in the planning, execution and interpretation of microarray studies. Recent technical advances allow for high-throughput study of specific cell populations and circuits. Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis.

(Received 1 May 2006; accepted after revision 21 June 2006; first published online 22 June 2006)
Corresponding author D. H. Geschwind: Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Email: dhg{at}mednet.ucla.edu




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J. Physiol., September 1, 2006; 575(2): 319 - 320.
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