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J Physiol Volume 575, Number 2, 379-387, September 1, 2006 DOI: 10.1113/jphysiol.2006.113449
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Topical Review

Transcriptional regulation of neuronal phenotype in mammals

Qiufu Ma1

1 Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA

Transcription factors (TFs) play pivotal roles in directing the formation of neurons and glia. Here I will review the recent genome-scale analysis of the expression of TFs in the developing mouse nervous system and discuss the logic by which TFs control the establishment of neuronal phenotype. Accumulating evidence suggests that while combinatorial action of TFs is able to define the basic framework of the nervous system, other control mechanisms, such as stochastic and epigenetic regulation of gene expression, also contribute to the generation of nerve cell diversity.

(Received 14 May 2006; accepted after revision 3 July 2006; first published online 6 July 2006)
Corresponding author Q. Ma: Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA. Email: qiufu_ma{at}dfci.harvard.edu




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