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This Article Full Text Full Text (PDF) All Versions of this Article: 576/1/203    most recent jphysiol.2006.113944v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by van Welie, I. Articles by Wadman, W. J. Search for Related Content PubMed PubMed Citation Articles by van Welie, I. Articles by Wadman, W. J. Related Collections Neuroscience

¹ Swammerdam Institute for Life Sciences - Center for NeuroScience, University of Amsterdam, 1090 GB Amsterdam, the Netherlands

Pyramidal neurons in the subiculum typically display either bursting or regular-spiking behaviour. Although this classification into two neuronal classes is well described, it is unknown how these two classes of neurons contribute to the integration of input to the subiculum. Here, we report that bursting neurons posses a hyperpolarization-activated cation current (I_h) that is two-fold larger (conductance, 5.3 ± 0.5 nS) than in regular-spiking neurons (2.2 ± 0.6 nS), whereas I_h exhibits similar voltage-dependent and kinetic properties in both classes of neurons. Bursting and regular-spiking neurons display similar morphology. The difference in I_h between the two classes of neurons is not responsible for the distinct firing patterns, as neither pharmacological blockade of I_h nor enhancement of I_h using a dynamic clamp affects the qualitative firing patterns. Instead, the difference in I_h between bursting and regular-spiking neurons determines the temporal integration of evoked synaptic input from the CA1 area. In response to stimulation at 50 Hz, bursting neurons, with a large I_h, show 50% less temporal summation than regular-spiking neurons. The amount of temporal summation in both neuronal classes is equal after pharmacological blockade of I_h. A computer simulation model of a subicular neuron with the properties of either a bursting or a regular-spiking neuron confirmed the pivotal role of I_h in temporal integration of synaptic input. These data suggest that in the subicular network, bursting neurons are better suited to discriminate the content of high-frequency input, such as that occurring during gamma oscillations, than regular-spiking neurons.

(Received 22 May 2006; accepted after revision 28 June 2006; first published online 29 June 2006)
Corresponding author W. J. Wadman: SILS – Center for NeuroScience, University of Amsterdam, PO Box 94084, 1090 GB Amsterdam, the Netherlands. Email: wadman{at}science.uva.nl

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