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Topical Review |
1 Departments of Neurobiology & Physiology and Communication Sciences & Disorders, The Neuroscience Institute, The Hugh Knowles Center, Northwestern University, Evanston, IL 60208, USA
In non-mammalian, hair cell-bearing sense organs amplification is associated with mechano-electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.
(Received 2 June 2006;
accepted after revision 27 July 2006;
first published online 27 July 2006)
Corresponding author P. Dallos: Department of Neurobiology & Physiology, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA. Email: p-dallos{at}northwestern.edu
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