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This Article Full Text Full Text (PDF) All Versions of this Article: 576/2/427    most recent jphysiol.2006.112128v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chang, P. Y. Articles by Jackson, M. B. Search for Related Content PubMed PubMed Citation Articles by Chang, P. Y. Articles by Jackson, M. B. Related Collections Neuroscience

¹ Department of Physiology and Biophysics Program, University of Wisconsin - Madison, 1300 University Ave, Madison WI 53706, USA

Although LTP (long-term potentiation) of synaptic transmission has received much attention as a model for learning and memory, its function within a neural circuit context remains poorly understood. To monitor LTP over an extensive circuit, we imaged responses in hippocampal slices using a voltage-sensitive dye. Following theta-burst stimulation, evoked optical signals showed an increase that lasted 40 min or more. Weak stimuli only potentiated the local area around the stimulating electrode, but stronger stimuli induced LTP over a wide area with a complex and non-uniform spatial pattern. The expression of LTP showed distinct peaks and valleys that depended on which axons were activated. Interestingly, the spatial distribution of LTP bore no relation to the spatial distribution of single-shock responses, but closely resembled the distribution of postsynaptic spikes evoked by theta bursts. Thus, postsynaptic spikes during induction constitute a critical determinant for the expression of LTP in intact circuits.

(Received 23 April 2006; accepted after revision 24 July 2006; first published online 27 July 2006)
Corresponding author M. B. Jackson: Department of Physiology, University of Wisconsin - Madison, 1300 University Ave, Madison, WI 53706, USA. Email: mjackson{at}physiology.wisc.edu

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