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J Physiol Volume 576, Number 3, 823-832, November 1, 2006 DOI: 10.1113/jphysiol.2006.116111
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NEUROSCIENCE

Peripheral amplification of sweating – a role for calcitonin gene-related peptide

Tanja Schlereth1, Jan Oliver Dittmar1, Bianca Seewald1 and Frank Birklein1

1 Department of Neurology, Johannes Gutenberg-University Langenbeckstr. 1, D-55101 Mainz, Germany

Neuropeptides are the mediators of neurogenic inflammation. Some pain disorders, e.g. complex regional pain syndromes, are characterized by increased neurogenic inflammation and by exaggerated sudomotor function. The aim of this study was to explore whether neuropeptides have a peripheral effect on human sweating. We investigated the effects of different concentrations of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and substance P (SP) on acetylcholine-induced axon reflex sweating in healthy subjects (total n = 18). All substances were applied via dermal microdialysis. The experiments were done in a parallel setting: ACh alone and ACh combined with CGRP, VIP or SP in various concentrations were applied. Acetylcholine (10–2 M) always elicited a sweating response, neuropeptides alone did not. However, CGRP significantly enhanced ACh-induced sweating (P < 0.01). Post hoc tests revealed that CGRP in physiological concentrations of 10–7–10–9 M was most effective. VIP at any concentration had no significant effect on axon reflex sweating. The duration of the sweating response (P < 0.01), but not the amount of sweat, was reduced by SP. ACh-induced skin blood flow was significantly increased by CGRP (P < 0.01), but unaltered by VIP and SP. The results indicate that CGRP amplifies axon reflex sweating in human skin.

(Received 28 June 2006; accepted after revision 17 August 2006; first published online 24 August 2006)
Corresponding author T. Schlereth, Department of Neurology, Johannes Gutenberg-University, Langenbeckstr. 1, D-55101 Mainz, Germany. Email: schleret{at}uni-mainz.de






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