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This Article Full Text Full Text (PDF) Supplemental data All Versions of this Article: 577/1/97    most recent jphysiol.2006.113050v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kasanetz, F. Articles by Murer, M. G. Search for Related Content PubMed PubMed Citation Articles by Kasanetz, F. Articles by Murer, M. G. Related Collections Neuroscience

¹ Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
² Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA

In vivo, cortical neurons and striatal medium spiny neurons (MSN) display robust subthreshold depolarizations (Up states) during which they are enabled to fire action potentials. In the cortex, Up states are believed to occur simultaneously in a neuronal ensemble and to be sustained by local network interactions. It is known that MSN are impelled into the Up state by extra-striatal (primarily cortical) inputs, but the mechanisms that sustain and determine the end of striatal Up states are still debated. Furthermore, it has not been established if brisk perturbations of ongoing cortical oscillations alter rhythmic transitions between Up and Down states in striatal neurons. Here we report that MSN Up states terminate abruptly when persistent activity in cortical ensembles providing afferents to a given striatal region is turned off by local electrical stimulation or ends spontaneously. In addition, we found that phase perturbations in MSN membrane potential slow oscillations induced by cortical stimulation replicate the stimulus-induced dynamics of spiking activity in cortical ensembles. Overall, these results suggest that striatal Up states are single-cell subthreshold representations of episodes of persistent spiking in cortical ensembles. A precise spatial and temporal alignment between episodes of cortical persistent activity and striatal Up states would allow MSN to detect specific cortical inputs embedded within a more general cortical signal.

(Received 8 May 2006; accepted after revision 23 August 2006; first published online 24 August 2006)
Corresponding author F. Kasanetz: Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina. Paraguay 2155 7°, (1121) Buenos Aires, Argentina. Email: ferkasa{at}fmed.uba.ar

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