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INTEGRATIVE |
1 Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
2 Copenhagen Muscle Research Center
3 Flight Medicine, Department of Cardiology, National Hospital, Copenhagen, Denmark
It is well established that metabolic inhibition of adrenergic vasoconstriction contributes to the maintenance of adequate perfusion to exercising skeletal muscle. However, little is known regarding nonadrenergic vasoconstriction during exercise. We tested the hypothesis that a non-adrenergic vasoconstrictor, angiotensin II (AngII), would be less sensitive to metabolic inhibition than an 
1-agonist, phenylephrine (PE), in the exercising human thigh. In 11 healthy men, femoral blood flow (FBF, ultrasound Doppler and thermodilution) and blood pressure were evaluated during wide-ranging doses of intra-arterial (femoral) infusions of PE and AngII at rest and during two workloads of steady-state knee-extensor exercise (7 W and 27 W). At rest, the maximal decrease in femoral artery diameter (FAD) during AngII (9.0 ± 0.2 to 8.4 ± 0.4 mm) was markedly less than during PE (9.0 ± 0.3 to 5.7 ± 0.5 mm), whereas maximal reductions in FBF and femoral vascular conductance (FVC) were similar during AngII (FBF: –65 ± 6 and FVC: –66 ± 6%) and PE (–57 ± 5 and –59 ± 4%). During exercise, FAD was not changed by AngII, but moderately decreased by PE. The maximal reductions in FBF and FVC were blunted during exercise compared to rest for both AngII (7 W: –28 ± 5 and –40 ± 5%; 27 W: –15 ± 4% and –29 ± 5%) and PE (7 W: –30 ± 4 and –37 ± 6%; 27 W: –15 ± 2 and –24 ± 6%), with no significant differences between drugs. The major new findings are (1) an exercise-induced intensity-dependent metabolic attenuation of non-adrenergic vasoconstriction in the human leg; and (2) functional evidence that AngII-vasoconstriction is predominantly distal, whereas 1-vasoconstriction is proximal and distal within the muscle vascular bed of the human thigh.
(Received 22 May 2006;
accepted after revision 8 September 2006;
first published online 14 September 2006)
Corresponding author M. Sander: Copenhagen Muscle Research Centre and Avitation Medicine Unit, Sect. 7522, Department of Cardiology, National Hospital, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark. Email: sanders{at}dadlnet.dk
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