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This Article Full Text Full Text (PDF) All Versions of this Article: 577/3/997    most recent jphysiol.2006.120006v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ropelle, E. R. Articles by Carvalheira, J. B. C. Search for Related Content PubMed PubMed Citation Articles by Ropelle, E. R. Articles by Carvalheira, J. B. C. Related Collections Skeletal Muscle and Exercise

¹ Department of Internal Medicine, State University of Campinas (UNICAMP), 13081-970-Campinas, São Paulo, Brazil

Lifestyle interventions including exercise programmes are cornerstones in the prevention of obesity-related diabetes. In this study, we demonstrate that a single bout of exercise inhibits high-fat diet-induced insulin resistance. Diet-induced obesity (DIO) increased the expression and activity of the protein tyrosine phosphatase 1B (PTP1B) and attenuated insulin signalling in gastrocnemius muscle of rats, a phenomenon which was reversed by a single session of exercise. In addition, DIO was observed to lead to serine phosphorylation of insulin receptor substrate 1 (IRS-1), which was also reversed by exercise in muscle in parallel with a reduction in c-Jun N-terminal kinase (JNK) activity. Thus, acute exercise increased the insulin sensitivity during high-fat feeding in obese rats. Overall, these results provide new insights into the mechanism by which exercise restores insulin sensitivity.

(Received 25 August 2006; accepted after revision 25 September 2006; first published online 28 September 2006)
Corresponding author J. B. C. Carvalheira: Departamento de Clínica, Médica, FCM-UNICAMP, Cidade Universitária Zeferino Vaz, Campinas, São Paulo, Brazil, 13081-970. Email: carvalheirajbc{at}uol.com.br

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