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J Physiol Volume 578, Number 1, 55-67, January 1, 2007 DOI: 10.1113/jphysiol.2006.120212
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Topical Review

Genetically encoded Ca2+ indicators: using genetics and molecular design to understand complex physiology

Michael I. Kotlikoff1

1 Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

This article reviews genetically encoded Ca2+ indicators (GECIs), with a focus on the use of these novel molecules in the context of understanding complex cell signalling in mammals, in vivo. The review focuses on the advantages and limitations of specific GECI design strategies and the results of experiments in which these molecules have been expressed in transgenic mice, concentrating particularly on recent experiments from our laboratory in which physiological signalling could be monitored in vivo. Finally, newer strategies for effective genetic specification of GECIs are briefly reviewed.

(Received 31 August 2006; accepted after revision 4 October 2006; first published online 12 October 2006)
Corresponding author M. I. Kotlikoff, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, T4018 VRT, Box 11, Ithaca, NY 14853-6401, USA. Email: mik7{at}cornell.edu




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