HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 579/3/893    most recent jphysiol.2006.124800v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Frasch, M. G. Articles by Schwab, M. Search for Related Content PubMed PubMed Citation Articles by Frasch, M. G. Articles by Schwab, M. Related Collections Integrative

¹ Department of Neurology
² Insitute of Laboratory Animal Science, Friedrich Schiller University, Jena, Germany
³ Department of Obstetrics and Gynaecology, Lawson Health Research Institute, University of Western Ontario, London, Canada
⁴ Institute of Medical Statistics, Computer Sciences and Documentation, Friedrich Schiller University, Jena, Germany
⁵ Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynaecology, University of Texas, San Antonio, TX, USA

Reduced birth weight predisposes to cardiovascular diseases in later life. We examined in fetal sheep at 0.76 (n = 18) and 0.87 (n = 17) gestation whether spontaneously occurring variations in fetal weight affect maturation of autonomic control of cardiovascular function. Fetal weights at both gestational ages were grouped statistically in low (LW) and normal weights (NW) (P < 0.01). LW fetuses were within the normal weight span showing minor growth dysproportionality at 0.76 gestation favouring heart and brain, with a primary growth of carcass between 0.76 and 0.87 gestation (P < 0.05). While twins largely contributed to LW fetuses, weight differences between singletons and twins were absent at 0.76 and modest at 0.87 gestation, underscoring the fact that twins belong to normality in fetal sheep not constituting a major malnutritive condition. Mean fetal blood pressure (FBP) of all fetuses was negatively correlated to fetal weight at 0.76 but not 0.87 gestation (P < 0.05). At this age, FBP and baroreceptor reflex sensitivity were increased in LW fetuses (P < 0.05), suggesting increased sympathetic activity and immaturity of circulatory control. Development of vagal modulation of fetal heart rate depended on fetal weight (P < 0.01). These functional associations were largely independent of twin pregnancies. We conclude, low fetal weight within the normal weight span is accompanied by a different trajectory of development of sympathetic blood pressure and vagal heart rate control. This may contribute to the development of elevated blood pressure in later life. Examination of the underlying mechanisms and consequences may contribute to the understanding of programming of cardiovascular diseases.

(Received 10 November 2006; accepted after revision 8 January 2007; first published online 11 January 2007)
Corresponding author M. Schwab: Department of Neurology, Friedrich Schiller University, D-07740 Jena, Germany. Email: matthias.schwab{at}med.uni-jena.de

This article has been cited by other articles:

				L. Bennet, L. C. Booth, N. Ahmed-Nasef, J. M. Dean, J. Davidson, J. S. Quaedackers, and A. J. Gunn Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1280 - R1286. [Abstract] [Full Text] [PDF]