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This Article Full Text Full Text (PDF) All Versions of this Article: 581/1/291    most recent jphysiol.2006.126409v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wellman, A. Articles by White, D. P. Search for Related Content PubMed PubMed Citation Articles by Wellman, A. Articles by White, D. P. Related Collections Respiratory

¹ Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
² Department of Biostatistics, Beth Israel Deaconess Medical Center, Boston, MA, USA

The prevalence of central apnoea and periodic breathing is increased in the elderly. This implies that the chemical control of breathing might become less stable with ageing. To investigate this, we measured loop gain in healthy elderly individuals using proportional assist ventilation. Loop gain is an engineering term that describes the stability of a system controlled by feedback loops, such as the respiratory control system. A loop gain close to zero indicates a stable system, whereas a loop gain close to or greater than one indicates an unstable system. Eleven healthy elderly subjects were studied with a mean ± S.D. age and body mass index (BMI) of 71 ± 5 years and 25 ± 3 kg m^–2, respectively. We also studied a small group of elderly individuals with obstructive sleep apnoea (OSA) for comparison (n = 3, age 68 ± 1 years, BMI 32 ± 11 kg m^–2). Comparisons were made with previously studied young individuals (age 27 ± 4 years, BMI 23 ± 1 kg m^–2). We found significantly lower loop gains in the healthy elderly group (loop gain 0.25) compared with the young group (loop gain 0.47, P = 0.001). Also, we found quite low loop gains in the elderly OSA group (loop gain 0.26). We conclude that the chemical control of breathing does not become unstable with ageing and is thus an unlikely cause of central (and possibly obstructive) apnoeas in this population.

(Received 12 December 2006; accepted after revision 19 February 2007; first published online 22 February 2007)
Corresponding author A. Wellman: Sleep Disorders Program @ BI, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Email: awellman{at}rics.bwh.harvard.edu

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