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This Article Full Text Full Text (PDF) All Versions of this Article: 582/1/17    most recent jphysiol.2007.130245v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Steele, D. F. Articles by Fedida, D. Search for Related Content PubMed PubMed Citation Articles by Steele, D. F. Articles by Fedida, D. Related Collections Review articles

¹ Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3

The regulation of ion channels involves more than just modulation of their synthesis and kinetics, as controls on their trafficking and localization are also important. Although the body of knowledge is fairly large, the entire trafficking pathway is not known for any one channel. This review summarizes current knowledge on the trafficking of potassium channels that are expressed in the heart. Our knowledge of channel assembly, trafficking through the Golgi apparatus and on to the surface is covered, as are controls on channel surface retention and endocytosis.

(Received 9 February 2007; accepted after revision 2 April 2007; first published online 5 April 2007)
Corresponding author D. Fedida: Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3. Email: fedida{at}interchange.ubc.ca