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This Article Full Text Full Text (PDF) Erratum (v584,p709) All Versions of this Article: 583/1/329    most recent jphysiol.2007.133454v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Soliz, J. Articles by Joseph, V. Search for Related Content PubMed PubMed Citation Articles by Soliz, J. Articles by Joseph, V. Related Collections Respiratory

¹ Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland
² Department of Pediatrics, Laval University, Center de Recherché (DO-711), Hôpital St-Francois d'Assise, 10 rue de l'Espinay, Quebec (QC), G1L 3L5, Canada

While erythropoietin (Epo) and its receptor (EpoR) have been widely investigated in brain, the expression and function of the soluble Epo receptor (sEpoR) remain unknown. Here we demonstrate that sEpoR, a negative regulator of Epo's binding to the EpoR, is present in the mouse brain and is down-regulated by 62% after exposure to normobaric chronic hypoxia (10% O₂ for 3 days). Furthermore, while normoxic minute ventilation increased by 58% in control mice following hypoxic acclimatization, sEpoR infusion in brain during the hypoxic challenge efficiently reduced brain Epo concentration and abolished the ventilatory acclimatization to hypoxia (VAH). These observations imply that hypoxic downregulation of sEpoR is required for adequate ventilatory acclimatization to hypoxia, thereby underlying the function of Epo as a key factor regulating oxygen delivery not only by its classical activity on red blood cell production, but also by regulating ventilation.

(Received 27 March 2007; accepted after revision 15 June 2007; first published online 21 June 2007)
Corresponding author J. Soliz: Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland. Email: jsoliz{at}access.uzh.ch

M. Gassmann and V. Joseph contributed equally to this work.

This article has been cited by other articles:

				J. Soliz, C. Soulage, E. Borter, M. T. van Patot, and M. Gassmann Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R649 - R658. [Abstract] [Full Text] [PDF]

				Errata J. Physiol., October 15, 2007; 584(2): 709 - 709. [Full Text] [PDF]

				J. Soliz, C. Soulage, D. M. Hermann, and M. Gassmann Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1702 - R1710. [Abstract] [Full Text] [PDF]