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J Physiol Volume 584, Number 1, 25-30, October 1, 2007 DOI: 10.1113/jphysiol.2007.139451
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TOPICAL REVIEW

Cell tracking using magnetic resonance imaging

 Mathias Hoehn1, Dirk Wiedermann1, Carles Justicia1, Pedro Ramos-Cabrer1, Klaus Kruttwig1, Tracy Farr1 and Uwe Himmelreich1

1 In-vivo-NMR Laboratory, Max-Planck-Institute for Neurological Research, Cologne, Germany

Cell tracking by in vivo magnetic resonance imaging (MRI) requires strategies of labelling the cells with MRI contrast agents. The principal routes to achieve efficient cell labelling for neurological applications are discussed with methodological advantages and caveats. Beyond temporo-spatial localization of labelled cells, the investigation of functional cell status is of great interest to allow studies of functional cell dynamics. The two major approaches to reach this goal, use of responsive contrast agents and generation of transgenic cell lines, are discussed.

(Received 22 June 2007; accepted after revision 7 August 2007; first published online 19 August 2007)
Corresponding author M. Hoehn: In-vivo-NMR Laboratory, Max-Planck-Institute for Neurological Research, Gleueler Strasse 50, D-50931 Köln, Germany. Email: mathias{at}nf.mpg.de






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