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This Article Full Text Full Text (PDF) All Versions of this Article: 584/1/31    most recent jphysiol.2007.136200v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Alvarez, F. J. Articles by Fyffe, R. E. W. Search for Related Content PubMed PubMed Citation Articles by Alvarez, F. J. Articles by Fyffe, R. E. W. Related Collections Review articles

¹ Department of Neuroscience, Cell Biology, and Physiology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA

Renshaw cell properties have been studied extensively for over 50 years, making them a uniquely well-defined class of spinal interneuron. Recent work has revealed novel ways to identify Renshaw cells in situ and this in turn has promoted a range of studies that have determined their ontogeny and organization of synaptic inputs in unprecedented detail. In this review we illustrate how mature Renshaw cell properties and connectivity arise through a combination of activity-dependent and genetically specified mechanisms. These new insights should aid the development of experimental strategies to manipulate Renshaw cells in spinal circuits and clarify their role in modulating motor output.

(Received 10 May 2007; accepted after revision 17 July 2007; first published online 19 July 2007)
Corresponding authors F. J. Alvarez: Department of Neuroscience, Cell Biology & Physiology, Boonshoft School of Medicine, Wright State University, 3640 Col. Glenn Hwy, Dayton, OH 45435, USA. Email: francisco.alvarez{at}wright.edu R. E. W. Fyffe: Email: robert.fyffe{at}wright.edu