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J Physiol Volume 585, Number 3, 687-691, December 15, 2007 DOI: 10.1113/jphysiol.2007.137539
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SYMPOSIUM REPORT

Activity-dependent control of bulk endocytosis by protein dephosphorylation in central nerve terminals

 Emma L. Clayton1, Gareth J. O. Evans1 and Michael A. Cousin1

1 Centre for Integrative Physiology, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK

Bulk endocytosis is the process by which nerve terminals retrieve large amounts of synaptic vesicle membrane during periods of strong stimulation intensity. The process is rapidly activated and is most probably calcium dependent in a similar manner to synaptic vesicle exocytosis. This article briefly summarizes the current knowledge of bulk endocytosis with respect to its activation, kinetics and molecular mechanism. It also presents recent data from our laboratory showing that the dephosphorylation of a group of endocytosis proteins called the dephosphins by the Ca2+-dependent protein phosphatase calcineurin is key to the activity-dependent stimulation of the process. Possible downstream effectors of calcineurin are discussed such as the large GTPase dynamin I and its phosphorylation-dependent interaction partner syndapin I.

(Received 29 May 2007; accepted after revision 18 June 2007; first published online 21 June 2007)
Corresponding author M. A. Cousin: Centre for Integrative Physiology, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK. Email: m.cousin{at}ed.ac.uk

This report was presented at a symposium on Multiple synaptic Vesicle retrieval pathways in neuronal physiology, which took place at the Life Sciences 2007 meeting, 9–12 July 2007, Glasgow, UK.




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