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This Article Full Text Full Text (PDF) All Versions of this Article: 586/13/3035    most recent jphysiol.2008.154997v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Bolotina, V. M. PubMed PubMed Citation Articles by Bolotina, V. M. Related Collections Review articles Cellular

¹ Ion Channel and Calcium Signaling Unit, Department of Medicine, Boston University School of Medicine, 650 Albany Street, X-704, Boston, MA 02118, USA

The mechanism of store-operated Ca²⁺ entry (SOCE) remains one of the intriguing mysteries in the field of Ca²⁺ signalling. Recent discoveries have resulted in the molecular identification of STIM1 as a Ca²⁺ sensor in endoplasmic reticulum, Orai1 (CRACM1) as a plasma membrane channel that is activated by the store-operated pathway, and iPLA₂β as an essential component of signal transduction from the stores to the plasma membrane channels. Numerous studies have confirmed that molecular knock-down of any one of these three molecules impair SOCE in a wide variety of cell types, but their mutual relations are far from being understood. This report will focus on the functional roles of Orai1, STIM1 and iPLA₂β, and will address some specific questions about Orai1 and TRPC1, and their relation to SOC channels in excitable and non-excitable cells. Also, it will analyse the novel role of STIM1 as a trigger for CIF production, and the complex relationship between STIM1 and Orai1 expression, puncta formation and SOCE activation. It will highlight some of the most recent findings that may challenge simple conformational coupling models of SOCE, and will offer some new perspectives on the complex relationships between Orai1, STIM1 and iPLA₂β in the SOCE pathway.

(Received 9 April 2008; accepted after revision 21 May 2008; first published online 22 May 2008)
Corresponding author V. M. Bolotina: Ion Channel and Calcium Signaling Unit, Department of Medicine, Boston University School of Medicine, 650 Albany Street, X-704, Boston, MA 02118, USA. Email: bolotina{at}bu.edu

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				A. B. Parekh Store-operated channels: mechanisms and function J. Physiol., July 1, 2008; 586(13): 3033 - 3033. [Full Text] [PDF]