J Physiol Society Membership
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Volume 586, Number 16, 3745-3749, August 15, 2008 DOI: 10.1113/jphysiol.2008.155713
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
586/16/3745    most recent
jphysiol.2008.155713v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Google Scholar
Right arrow Articles by Markwardt, S.
Right arrow Articles by Overstreet-Wadiche, L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Markwardt, S.
Right arrow Articles by Overstreet-Wadiche, L.
Related Collections
Right arrow Review articles
Right arrow Neuroscience

SYMPOSIUM REPORT

GABAergic signalling to adult-generated neurons

 Sean Markwardt1 and Linda Overstreet-Wadiche1

1 Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA

New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step-wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity-dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis.

(Received 22 April 2008; accepted after revision 28 May 2008; first published online 29 May 2008)
Corresponding author L. Overstreet-Wadiche: Neurobiology Department, Shel 1003, University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA. Email: lwadiche{at}uab.edu

This report was presented at The Journal of Physiology Symposium on The role of GABA and glutamate on adult neurogenesis, which took place at Experimental Biology 2008, San Diego, CA, USA, 9 April 2008. It was commissioned by the Editorial Board and reflects the views of the authors.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
A. J. Eisch, H. A. Cameron, J. M. Encinas, L. A. Meltzer, G.-L. Ming, and L. S. Overstreet-Wadiche
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?
J. Neurosci., November 12, 2008; 28(46): 11785 - 11791.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Vicini
The role of GABA and glutamate on adult neurogenesis
J. Physiol., August 15, 2008; 586(16): 3737 - 3738.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 The Physiological Society.