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This Article Full Text Full Text (PDF) All Versions of this Article: 586/18/4401    most recent jphysiol.2008.156695v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Kern, T. S. Articles by Barber, A. J. PubMed PubMed Citation Articles by Kern, T. S. Articles by Barber, A. J. Related Collections Review articles Neuroscience

¹ Departments of Medicine and Ophthalmology, Case Western Reserve University, Cleveland, OH, USA and Cleveland VAMC Research Service 151, Cleveland, OH, USA
² The Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, and the Juvenile Diabetes Research Foundation Diabetic Retinopathy Center and Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA

Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting in dysfunction and even degeneration of some neuronal cells. Retinal ganglion cells (RGCs) are the best studied of the retinal neurons with respect to the effect of diabetes. Although investigations are providing new information about RGCs in diabetes, including therapies to inhibit the neurodegeneration, critical information about the function, anatomy and response properties of these cells is yet needed to understand the relationship between RGC changes and visual dysfunction in diabetes.

(Received 10 May 2008; accepted after revision 4 June 2008; first published online 19 June 2008)
Corresponding author T. S Kern: Center for Diabetes Research, Dept of Medicine, 434 Biomedical Research Building, Case Western Reserve University, 0900 Euclid Ave, Cleveland, OH 44106, USA.  Email: tsk{at}case.edu

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