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This Article Full Text Full Text (PDF) All Versions of this Article: 586/6/1503    most recent jphysiol.2008.150722v1 Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Dölen, G. Articles by Bear, M. F. PubMed PubMed Citation Articles by Dölen, G. Articles by Bear, M. F. Related Collections Review articles Neuroscience

¹ Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
² Brown Medical School, Providence, RI, USA

Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.

(Received 3 January 2008; accepted after revision 11 January 2007; first published online 17 January 2007)
Corresponding author M. F. Bear: Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Email: mbear{at}mit.edu

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