| Data Collection for: |
Journal of Physiology (2002), 542.2, pp. 549-557 |
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Proton accumulation plays a role in the amplitude,
but not in the time for the onset, of the vascular response to anodal current-induced
vasodilatation
Protocols were designed to test the influence of alternate anionic and cationic
buffers on the amplitude and time for the onset of anodal current-induced vasodilatation.
We used four different vehicles: (a) deionised water, (b) sodium bicarbonate
(250 mM in deionised water), (c) sodium acetate (250
mM in deionised water) and (d) sodium chloride (125 mM
in deionised water), on eight subjects and performed 5 min anodal current applications.
LDFrest was 6.9 ± 3.0, 7.6 ± 3.3, 7.5 ± 2.0,
6.1 ± 3.4 %MVD for (a), (b), (c) and (d), respectively. LDFpeak
was 15.8 ± 14.3 %MVD for (b) (P < 0.05 vs. all other
solutions). It was 49.8 ± 26.4 %MVD for (c) and 69.8 ± 40.9 %MVD
for (d), not significantly different from (a): 65.8 ± 36.5 %MVD. Estimation
of the time for the onset of vasodilatation showed no change with the different
solutions. In anodal iontophoresis, bicarbonate solution vehicles should probably
be preferred to deionised water to decrease the amplitude of the 'non-specific'
response to current application. The cause for the delay of vasodilatation is
still unsolved.
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Prepared by: Durand et al., 15 July 2002.
