J Physiol Boston Smyposia
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A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel
J Physiol Niemeyer et al. 553: 873

Effect of pH on gating of ClC-2 and E217V mutant

The results show the lack of effect of intracellular acidification to pH 5.7 upon ClC-2 activity. In addition the effects of changing extracellular pH betwee 5.5 and 11.0 on ClC-2 and its E217V mutant are illustrated.

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