J Physiol Boston Smyposia
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on December 3, 2001.
 Copyright © 2001 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
538/2/619    most recent
2001.012888v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alam, M. N.
Right arrow Articles by Szymusiak, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Alam, M. N.
Right arrow Articles by Szymusiak, R.

Received June 25, 2001
Accepted after revision September 28, 2001

Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area

Md Noor Alam1, Hui Gong2, Tarannum Alam1, Rajesh Jaganath3, Dennis McGinty4, and Ronald Szymusiak5*

1 Department of Psychology, School of Medicine, University of California, Los Angeles, CA 90024, USA
2 Research Service, V.A. Greater Los Angeles Healthcare System, North Hills, CA 91343, and Department of Psychology, School of Medicine, University of California, Los Angeles, CA 90024, USA
3 Research Service, V.A. Greater Los Angeles Healthcare System, North Hills, CA 91343, USA
4 Research Service, V.A. Greater Los Angeles Healthcare System, North Hills, CA 91343 and Department of Psychology, School of Medicine, University of California, Los Angeles, CA 90024, USA
5 Research Service, V.A. Greater Los Angeles Healthcare System, North Hills, CA 91343 and Departments of Medicine and Neurobiology, School of Medicine, University of California, Los Angeles, CA 90024, USA

* To whom correspondence should be addressed. E-mail: rszym{at}ucla.edu.

The perifornical lateral hypothalamic area (PF-LHA) has been implicated in the control of several waking behaviours, including feeding, motor activity and arousal. Several cell types are located in the PF-LHA, including projection neurons that contain the hypocretin peptides (also known as orexins). Recent findings suggest that hypocretin neurons are involved in sleep-wake regulation. Loss of hypocretin neurons in the human disorder narcolepsy is associated with excessive somnolence, cataplexy and an enhanced propensity for rapid eye movement (REM) sleep. However, the relationship of PF-LHA neuronal activity to different arousal states is unknown. We recorded neuronal activity in the PF-LHA of rats during natural sleep and waking. Neuronal discharge rates were calculated during active waking (waking accompanied by movement), quiet waking, non-REM sleep and REM sleep. Fifty-six of 106 neurons (53 %) were classified as wake/REM-related. These neurons exhibited peak discharge rates during waking and REM sleep and reduced discharge rates during non-REM sleep. Wake-related neurons (38 %) exhibited reduced discharge rates during both non-REM and REM sleep when compared to that during waking. Wake-related neurons exhibited significantly higher discharge rates during active waking than during quiet waking. The discharge of wake-related neurons was positively correlated with muscle activity across all sleep-waking states. Recording sites were located within the hypocretin-immunoreactive neuronal field of the PF-LHA. Although the neurotransmitter phenotype of recorded cells was not determined, the prevalence of neurons with wake-related discharge patterns is consistent with the hypothesis that the PF-LHA plays a role in the regulation of arousal, muscle activity and sleep-waking states.




This article has been cited by other articles:


Home page
 J. Physiol.Home page
J. W. Lu, V. B. Fenik, J. L. Branconi, G. L. Mann, I. Rukhadze, and L. Kubin
Disinhibition of perifornical hypothalamic neurones activates noradrenergic neurones and blocks pontine carbachol-induced REM sleep-like episodes in rats
J. Physiol., July 15, 2007; 582(2): 553 - 567.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Suntsova, R. Guzman-Marin, S. Kumar, Md. N. Alam, R. Szymusiak, and D. McGinty
The Median Preoptic Nucleus Reciprocally Modulates Activity of Arousal-Related and Sleep-Related Neurons in the Perifornical Lateral Hypothalamus
J. Neurosci., February 14, 2007; 27(7): 1616 - 1630.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. d. Lecea, B. E. Jones, B. Boutrel, S. L. Borgland, S. Nishino, M. Bubser, and R. DiLeone
Addiction and Arousal: Alternative Roles of Hypothalamic Peptides
J. Neurosci., October 11, 2006; 26(41): 10372 - 10375.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Tamakawa, A. Karashima, Y. Koyama, N. Katayama, and M. Nakao
A Quartet Neural System Model Orchestrating Sleep and Wakefulness Mechanisms
J Neurophysiol, April 1, 2006; 95(4): 2055 - 2069.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Takakusaki, K. Takahashi, K. Saitoh, H. Harada, T. Okumura, Y. Kayama, and Y. Koyama
Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
J. Physiol., November 1, 2005; 568(3): 1003 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. G. Lee, O. K. Hassani, and B. E. Jones
Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
J. Neurosci., July 13, 2005; 25(28): 6716 - 6720.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. S. Levine, R. Winsky-Sommerer, S. Huitron-Resendiz, M. K. Grace, and L. de Lecea
Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1727 - R1732.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Md. N. Alam, S. Kumar, T. Bashir, N. Suntsova, M. M Methippara, R. Szymusiak, and D. McGinty
GABA-mediated control of hypocretin- but not melanin-concentrating hormone-immunoreactive neurones during sleep in rats
J. Physiol., March 1, 2005; 563(2): 569 - 582.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Winsky-Sommerer, A. Yamanaka, S. Diano, E. Borok, A. J. Roberts, T. Sakurai, T. S. Kilduff, T. L. Horvath, and L. de Lecea
Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
J. Neurosci., December 15, 2004; 24(50): 11439 - 11448.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Mochizuki, A. Crocker, S. McCormack, M. Yanagisawa, T. Sakurai, and T. E. Scammell
Behavioral State Instability in Orexin Knock-Out Mice
J. Neurosci., July 14, 2004; 24(28): 6291 - 6300.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Gong, D. McGinty, R. Guzman-Marin, K.-T. Chew, D. Stewart, and R. Szymusiak
Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation
J. Physiol., May 1, 2004; 556(3): 935 - 946.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M.-F. Wu, J. John, N. Maidment, H. A. Lam, and J. M. Siegel
Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1079 - R1086.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. I. Kiyashchenko, B. Y. Mileykovskiy, N. Maidment, H. A. Lam, M.-F. Wu, J. John, J. Peever, and J. M. Siegel
Release of Hypocretin (Orexin) during Waking and Sleep States
J. Neurosci., July 1, 2002; 22(13): 5282 - 5286.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2001 The Physiological Society.