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Received February 17, 2002
Accepted after revision April 8, 2002
1 Room WB210, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
2 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada
* To whom correspondence should be addressed. E-mail: Manuel-Castro{at}bic.mni.mcgill.ca.
During disinhibition the neocortex generates synchronous activities. In neocortical slices application of GABAA and GABAB receptor antagonists transforms slow oscillations into large amplitude spike-wave discharges that contain a rhythmic ~10 Hz neocortical oscillation. The 10 Hz oscillations caused by disinhibition are highly region specific and are generated only in frontal agranular regions of neocortex, such as the primary motor cortex, but not in granular neocortex. Pharmacological manipulations show that the 10 Hz oscillations are critically dependent on 
-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors. Current source density (CSD) analyses in slices using 16-site silicon probes revealed that the 10 Hz oscillations are expressed with large current sinks in the upper layers and smaller current sinks in the lower layers that precede them. The results indicate that blocking GABAB receptors in the agranular neocortex unmasks recurrent synaptic activity mediated by AMPA receptors that results in the generation of these oscillations.
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