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First published online on May 17, 2002.
 Copyright © 2002 by The Physiological Society
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2002.020024v1
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Received March 6, 2002
Accepted after revision April 12, 2002

Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones

Attila Losonczy1, Limei Zhang2, Ryuichi Shigemoto3, Peter Somogyi4, and Z. Nusser5*

1 Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Budapest, Hungary
2 Medical Research Council, Anatomical Neuropharmacology Unit, University Department of Pharmacology, Oxford, UK
3 Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, CREST Japan Science and Technology Corporation, Japan
4 Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Budapest, Hungary, and Medical Research Council, Anatomical Neuropharmacology Unit, University Department of Pharmacology, Oxford, UK
5 Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary

* To whom correspondence should be addressed. E-mail: nusser{at}koki.hu.

Synapses exhibit different short-term plasticity patterns and this behaviour influences information processing in neuronal networks. We tested how the short-term plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic cell type, identified by axonal arborizations and molecular markers in the hippocampal CA1 area. Three distinct types of short-term synaptic behaviour (facilitating, depressing and combined facilitating-depressing) were defined by fitting a dynamic neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare (O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive for somatostatin and mGluR1{alpha} and all tested cells were decorated by strongly mGluR7a positive axon terminals. Responses in eight of 12 basket cells were described well with a model involving only depression, but the other cells displayed combined facilitating-depressing EPSCs. No apparent difference was found between the plasticity of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing, and the remaining five cells combined facilitating-depressing EPSCs. Seven of 10 cells tested for somatostatin were immunopositive, but mGluR1{alpha} was detectable only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic responses to action potentials recorded in vivo from a CA1 place cell were modelled, and revealed great differences between and within cell types. Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations.




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