J Physiol Society Meetings
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on July 26, 2002.
 Copyright © 2002 by The Physiological Society
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
543/3/767    most recent
2002.025668v1
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huang, C.-C.
Right arrow Articles by Hsu, K.-S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Huang, C.-C.
Right arrow Articles by Hsu, K.-S.

Received May 31, 2002
Accepted after revision June 11, 2002

Role for cAMP and protein phosphatase in the presynaptic expression of mouse hippocampal mossy fibre depotentiation

Chiung-Chun Huang1, Yea-Lin Chen1, Ying-Ching Liang1, and K.-S. Hsu1*

1 Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan

* To whom correspondence should be addressed. E-mail: richard{at}mail.ncku.edu.tw.

Long-term potentiation (LTP) at the hippocampal mossy fibre-CA3 synapses can be reversed (depotentiated) by long trains of low-frequency stimulation (LFS). In the present study, we showed that this depotentiation is triggered by a presynaptic group II metabotropic glutamate receptor (mGluR), which reduces cytosolic cAMP level, leading to a reversal of cellular processes responsible for mossy fibre LTP expression. Furthermore, we found that both of the presynaptic activity-induced elevation of Ca2+ and the activation of protein phosphatase (PP) activity are required for the induction of depotentiation. Thus, we conclude that mossy fibre depotentiation is expressed presynaptically through the activation of both presynaptic mGluR- and PP-coupled signalling cascades, and that the bidirectional long-term plasticity at the mossy fibre-CA3 synapses is likely to be regulated by presynaptic Ca2+-dependent processes.




This article has been cited by other articles:


Home page
 Mol. Pharmacol.Home page
C.-C. Huang and K.-S. Hsu
Presynaptic Mechanism Underlying cAMP-Induced Synaptic Potentiation in Medial Prefrontal Cortex Pyramidal Neurons
Mol. Pharmacol., March 1, 2006; 69(3): 846 - 856.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C.-C. Huang and K.-S. Hsu
Local protein synthesis and GABAB receptors regulate the reversibility of long-term potentiation at murine hippocampal mossy fibre-CA3 synapses
J. Physiol., November 15, 2004; 561(1): 91 - 108.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Wang, M. F. Yeckel, D. Johnston, and R. S. Zucker
Photolysis of Postsynaptic Caged Ca2+ Can Potentiate and Depress Mossy Fiber Synaptic Responses in Rat Hippocampal CA3 Pyramidal Neurons
J Neurophysiol, April 1, 2004; 91(4): 1596 - 1607.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2002 The Physiological Society.